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Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

Laing, Gavin, Yarleque, A., Marcelo, A., Rodriguez, E., Warrell, David A. and Theakston, R.David G. (2004) 'Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms'. Toxicon, Vol 44, Issue 1, pp. 103-106.

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Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: Erratum: http://www.sciencedirect.com/science/article/pii/S0041010104002818
Uncontrolled Keywords: south american antivenoms peru in vivo tests in vitro tests world health organization lachesis-muta bites
Subjects: QV Pharmacology > Toxicology > General Toxicology > QV 601 Antidotes and other therapeutic measures
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 400 General works
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.toxicon.2004.03.020
Depositing User: Sarah Lewis-Newton
Date Deposited: 16 Mar 2012 15:53
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2228

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