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Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Nzila, Alexis, Kokwaro, G., Winstanley, P. A., Marsh, Kevin and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2004) 'Therapeutic potential of folate uptake inhibition in Plasmodium falciparum'. Trends in Parasitology, Vol 20, Issue 3, pp. 109-112.

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Abstract

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

Item Type: Article
Uncontrolled Keywords: pyrimethamine-sulfadoxine resistance dihydrofolate-reductase in-vitro methotrexate resistance membrane-transport folic-acid malaria efficacy family mechanisms
Subjects: QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QX Parasitology > Protozoa > QX 135 Plasmodia
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2003.12.005
Depositing User: Sarah Lewis-Newton
Date Deposited: 17 May 2012 09:18
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2241

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