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Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Nzila, Alexis, Kokwaro, G., Winstanley, P. A., Marsh, Kevin and Ward, Stephen (2004) 'Therapeutic potential of folate uptake inhibition in Plasmodium falciparum'. Trends in Parasitology, Vol 20, Issue 3, pp. 109-112.

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Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

Item Type: Article
Uncontrolled Keywords: pyrimethamine-sulfadoxine resistance dihydrofolate-reductase in-vitro methotrexate resistance membrane-transport folic-acid malaria efficacy family mechanisms
Subjects: QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QX Parasitology > Protozoa > QX 135 Plasmodia
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
Depositing User: Sarah Lewis-Newton
Date Deposited: 17 May 2012 09:18
Last Modified: 06 Feb 2018 13:03


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