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Male-specific insecticide resistance and mosquito transgene dispersal

Sinkins, Steven P. and Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X (2004) 'Male-specific insecticide resistance and mosquito transgene dispersal'. Trends in Parasitology, Vol 20, Issue 9, pp. 413-416.

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Abstract

There is a need to develop methods to spread disease-blocking transgenes through mosquito populations. This article discusses the possibility of linking transgenes to insecticide-resistant alleles engineered to be expressed only in males. The resulting increase in mean longevity of males carrying the construct under insecticide treatment could easily outweigh any fitness costs in females, so that the construct would spread rapidly. It should be possible to produce constructs where any potential risk of loss of male-specific expression would be negligible.

Item Type: Article
Uncontrolled Keywords: yellow-fever mosquito lethal genetic system anopheles-gambiae malaria vector aedes-aegypti germline transformation culex-pipiens transmission populations mechanisms
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 525 Aedes
QX Parasitology > Insects. Other Parasites > QX 530 Culex
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2004.07.003
Depositing User: Martin Chapman
Date Deposited: 05 Mar 2012 15:07
Last Modified: 06 Feb 2018 13:03
URI: https://archive.lstmed.ac.uk/id/eprint/2242

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