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Development of venom toxin-specific antibodies by DNA immunisation: rationale and strategies to improve therapy of viper envenoming

Harrison, Robert (2004) 'Development of venom toxin-specific antibodies by DNA immunisation: rationale and strategies to improve therapy of viper envenoming'. Vaccine, Vol 22, Issue 13-14, pp. 1648-1655.

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Abstract

DNA vaccination induces potent cellular immune responses against infectious and parasitic intracellular pathogens. This paper illustrates that DNA immunisation protocols can be adapted to induce high titre antibody responses with potential to improve the treatment of systemic snake envenoming that kills 20,000 people annually in Africa. Envenoming by the saw-scaled vipers and puff adders are responsible for the majority of these deaths. DNA sequences encoding haemorrhagic, pro- and anti-coagulant and other haemostasis-disruptive venom toxins from these vipers showed extensive cross-specific and cross-generic sequence and structural similarities. The predicted antigenic profiles of these toxin sequences are utilised to design DNA immunisation constructs to generate toxin-specific antibodies with potential to polyspecifically neutralise venoms from the most medically-important African vipers. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: echis ocellatus echis pyramidum leakeyi bitis arietans sequence conservation c-type lectins metalloproteinases phospholipases a(2) serine proteases bothrops-jararaca venom metalloproteinase jararhagin hemorrhagic metalloprotease accelerated evolution platelet-aggregation phospholipase a(2) echis-carinatus immune-response snake-venoms gene family
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.vaccine.2003.09.046
Depositing User: Martin Chapman
Date Deposited: 30 Aug 2012 14:37
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2255

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