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Elicitation of Mucosal Immunity by Proteins of Streptococcus pneumoniae

Briles, David E., Miyaji, Eliane, Fukuyama, Yoshiko, Ferreira, Daniela ORCID: https://orcid.org/0000-0001-7730-9477 and Fujihashi, Kohtaro (2011) 'Elicitation of Mucosal Immunity by Proteins of Streptococcus pneumoniae' in: Harabuchi, Y., Hayashi, T. and Katada, A., (eds) Recent advances in tonsils and mucosal barriers of the upper airways, 72, Basel, Karger, pp. 25-27.

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Abstract

Pneumococcal diseases such as otitis media, pneumonia,
and meningitis are invariably preceded by nasopharyngeal
colonization, and herd immunity against pneumococcal disease requires protection against colonization. An early study in mice demonstrated that mucosal immunization with cholera toxin B subunit as adjuvant could elicit solid mucosal immunity. Recent data from several laboratories provides support for three different mechanisms by which adaptive immunity can provide protection against colonization. (1) IL- 17- dependent T cell immunity can recruit PMN to sites of colonization. This IL-
17- dependent immunity can be elicited by immunization
with antigen plus a mucosal adjuvant, or can be elicited
by colonization itself. (2) Immunity against colonization
can be mediated by mucosal IgA and at the mucosal surface
passive mucosal IgA antibody provides much better
protection against carriage than passive IgG antibody. (3)
Complement- fixing IgG antibody can protect against colonization and may act by protecting against colonization
of bacteria

Item Type: Book Section
Additional Information: 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways, Asahikawa, July 2010: Proceedings
Subjects: QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WV Otolaryngology > Pharyngeal Region > WV 400 General works
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1159/000324589
Depositing User: Users 43 not found.
Date Deposited: 18 Nov 2011 16:20
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2400

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