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Toll-like receptor polymorphisms in malaria-endemic populations.

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Greene, Jennifer A., Moormann, Ann M., Vulule, John, Bockarie, Moses, Zimmerman, Peter A. and Kazura, James W. (2009) 'Toll-like receptor polymorphisms in malaria-endemic populations.'. Malaria Journal, Vol 8, p. 50.

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Abstract

Similar frequencies of TLR2, TLR4, TLR9, and MAL genetic polymorphisms in populations with different histories of malaria exposure suggest that these innate immune pathways have not been under strong selective pressure by malaria. Genotype frequencies are consistent with Hardy-Weinberg Equilibrium and the Neutral Theory, suggesting that genetic drift has influenced allele frequencies to a greater extent than selective pressure from malaria or any other infectious agents in these populations.

Item Type: Article
Additional Information: The original version of this article is available at: http://archive.lstmliverpool.ac.uk/2421/1/Greene_et_al_malariajournal_toll-like_receptor_polymorphisms.pdf
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Disease Control Strategy Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1475-2875-8-50
Depositing User: Users 322 not found.
Date Deposited: 11 Nov 2011 12:14
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2421

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