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Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations

Clark, T. G., Diakite, M., Auburn, S., Campino, S., Fry, A. E., Green, A., Richardson, A., Small, K., Teo, Y. Y., Wilson, J., Jallow, M., Sisay-Joof, F., Pinder, M., Griffiths, M. J., Peshu, N., Williams, T. N., Marsh, Kevin, Molyneux, Malcolm E, Taylor, T. E., Rockett, K. A. and Kwiatkowski, D. P. (2009) 'Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations'. Journal of Infectious Disease, Vol 199, Issue 4, pp. 569-575.

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Abstract

The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF - 238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
QU Biochemistry > Genetics > QU 475 Genetic processes
QU Biochemistry > Genetics > QU 470 Genetic structures
Digital Object Identifer (DOI): https://doi.org/10.1086/596320
Depositing User: Users 43 not found.
Date Deposited: 22 Jun 2010 10:44
Last Modified: 07 Dec 2018 09:58
URI: https://archive.lstmed.ac.uk/id/eprint/243

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