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Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

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Mubjer, Reem A, Adeel, Ahmed A, Chance, Michael and Hassan, Amir (2011) 'Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.'. Malaria Journal, Vol 10, p. 245.

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Abstract

This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum parasites from Yemen. Mutant pfcrtT76 is highly prevalent but it is a poor predictor of treatment failure in the study population. The prevalence of mutation dhfrArg59 is suggestive of emerging resistance to SP, which is currently a component of the recommended combination treatment of falciparum malaria in Yemen. More studies on these markers are recommended for surveillance of resistance in the study area.

Item Type: Article
Subjects: QV Pharmacology > QV 38 Drug action.
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1475-2875-10-245
Depositing User: Mary Creegan
Date Deposited: 15 Nov 2011 14:29
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2433

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