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The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

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Shi, Jianguo, McIntosh, Richard S., Adame-Gallegos, Jaime, Dehal, Prabhjyot K., van Egmond, Marjolein, van de Winkel, Jan, Draper, Simon J., Forbes, Emily K., Corran, Patrick H., Holder, Anthony A., Woof, Jenny M. and Pleass, Richard ORCID: https://orcid.org/0000-0001-7438-8296 (2011) 'The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).'. BMC biotechnology, Vol 11, p. 77.

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Abstract

The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1472-6750-11-77
Depositing User: Mary Creegan
Date Deposited: 02 Dec 2011 11:05
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2443

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