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Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil

Cartaxo, Marina F.S., Ayres, Constância F.J. and Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 (2011) 'Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 105, Issue 9, pp. 491-499.

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Abstract

Recife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1 REC) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1REC does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program.

Item Type: Article
Uncontrolled Keywords: Culex quinquefasciatus; Bacillus sphaericus; Lymphatic filariasis; Microsatellite; Genetic drift; Receptor gene cqm1
Subjects: QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.trstmh.2011.05.004
Depositing User: Users 183 not found.
Date Deposited: 04 Jan 2012 10:51
Last Modified: 07 Sep 2019 13:07
URI: https://archive.lstmed.ac.uk/id/eprint/2461

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