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Zinc supplementation in Brazilian children with acute diarrhoea

Al-Sonboli, N., Gurgel, R. Q., Shenkin, A., Hart, C. Anthony and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2003) 'Zinc supplementation in Brazilian children with acute diarrhoea'. Annals of Tropical Paediatrics, Vol 23, Issue 1, pp. 3-8.

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Abstract

Although oral rehydration therapy greatly reduces mortality from diarrhoeal diseases, it has little effect on stool frequency. However, there is mounting evidence that zinc is an effective adjunct to the treatment of diarrhoea, although few studies have examined its efficacy in Latin America. This study assessed the efficacy of zinc supplementation in children with acute diarrhoea in Brazil. The study was a double-blind, placebo-controlled, randomised, clinical trial in children < 5 years of age attending emergency services in Sergipe, Brazil. Subjects received zinc or vitamin C as placebo. There was a marked reduction in the duration of the diarrhoea (1.1 vs 2.6 days) and of watery stools in the zinc-supplemented group. The efficacy of zinc was independent of the presence of viral enteropathogens in the stools. It is concluded that, similar to studies in India and Bangladesh, zinc could be an important adjunct for treating acute diarrhoea in Brazilian children.

Item Type: Article
Subjects: QV Pharmacology > Dermatologic Agents. Gastrointestinal Agents > QV 71 Antidiarrheals
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 312 Diarrheal disorders
WS Pediatrics > By Age Groups > WS 430 Infancy
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1179/000349803125002797
Depositing User: Martin Chapman
Date Deposited: 12 Jun 2013 12:30
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2495

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