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Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp in Wuchereria bancrofti with Doxycycline

Debrah, A. Y., Mand, S., Marfo-Debrekyei, Y., Batsa, L., Pfarr, K., Lawson, B., Taylor, Mark, Adjei, O. and Hoerauf, A. (2009) 'Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp in Wuchereria bancrofti with Doxycycline'. American Journal of Tropical Medicine and Hygiene, Vol 80, Issue 6, pp. 956-963.

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Abstract

The treatment for hydrocele is expensive, invasive surgery-hydrocelectomy. A drug that could prevent or improve this condition could replace or supplement hydrocelectomy. In Ghana, 42 hydrocele patients participated in a double-blind, placebo-controlled trial of a six-week regimen of doxycycline, 200 mg/day. Four months after doxycycline treatment. patients received 150 mu g/kg of ivermectin and 400 mg of albendazole, which is used for mass chemotherapy in this area. Patients were monitored for levels of Wolbachia sp., microfilaremia, antigenemia, plasma levels of vascular endothelial growth factor-A (VEGF-A) and stage/size of the hydrocele. Wolbachia sp. loads/microfilaria, microfilaremia, and antigenemia were significantly reduced in the doxycycline-treated patients compared with the placebo group. The mean plasma levels of VEGF-A were decreased significantly in the doxycycline-treated patients who had active infection. This finding preceded the reduction of the stage of hydrocele. A six-week regimen of doxycycline treatment against filariasis showed amelioration of pathologic conditions of hydrocele patients with active infection.

Item Type: Article
Additional Information: Debrah, Alexander Y. Mand, Sabine Marfo-Debrekyei, Yeboah Batsa, Linda Pfarr, Kenneth Lawson, Bernard Taylor, Mark Adjei, Ohene Hoerauf, Achim
Uncontrolled Keywords: Ghana, Wolbachia sp., Wuchereria bancrofti, Hydrocele, Lymphatic filariasis
Subjects: WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Depositing User: Mary Creegan
Date Deposited: 27 Apr 2010 15:45
Last Modified: 06 Feb 2018 12:59
URI: https://archive.lstmed.ac.uk/id/eprint/250

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