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Do disturbances within the folate pathway contribute to low birth weight in malaria?

Brabin, Bernard, Fletcher, K. A. and Brown, Nicolas (2003) 'Do disturbances within the folate pathway contribute to low birth weight in malaria?'. Trends in Parasitology, Vol 19, Issue 1, pp. 39-43.

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Abstract

The evidence implicating Plasmodium falciparum malaria as a cause of low birth weight and intrauterine growth retardation is overwhelming, especially in women with their first pregnancies, who are more susceptible to falciparum malaria than non-pregnant women or those in subsequent pregnancies. The mechanisms that explain these outcomes are unknown, but are important because malaria during pregnancy causes low birth weight in millions of babies, worldwide. This article examines the evidence for the hypothesis that functional impairment of the folate metabolic pathway associated with P. falciparum infection in pregnancy might contribute to fetal growth retardation.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases
WS Pediatrics > WS 20 Research (General)
WS Pediatrics > By Age Groups > WS 420 Newborn infants. Neonatology
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1016/s1471-4922(02)00004-1
Depositing User: Sarah Lewis-Newton
Date Deposited: 18 Jul 2012 16:21
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2506

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