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Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Bray, Patrick, Barrett, Micheal P., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and de Koning, Harry P. (2003) 'Pentamidine uptake and resistance in pathogenic protozoa: past, present and future'. Trends in Parasitology, Vol 19, Issue 5, pp. 232-239.

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Abstract

Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 254 Antiprotozoal agents (General)
QX Parasitology > Protozoa > QX 50 Protozoa
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 700 Protozoan infections (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/s1471-4922(03)00069-2
Depositing User: Users 476 not found.
Date Deposited: 15 Nov 2012 11:19
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2507

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