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Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria

Grau, G. E., Mackenzie, C. D., Carr, R. A., Redard, M., Pizzolato, G., Allasia, C., Cataldo, C., Taylor, T. E. and Molyneux, Malcolm E (2003) 'Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria'. Journal of Infectious Disease, Vol 187, Issue 3, pp. 461-466.

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The pathogenesis of fatal cerebral malaria (CM) is not well understood, in part because data from patients in whom a clinical diagnosis was established prior to death are rare. In a murine CM model, platelets accumulate in brain microvasculature, and antiplatelet therapy can improve outcome. We determined whether platelets are also found in cerebral vessels in human CM, and we performed immunohistopathology for platelet-specific glycoprotein, GPIIb-IIIa, on tissue from multiple brain sites in Malawian children whose fatal illness was severe malarial anemia, CM, or nonmalarial encephalopathy. Platelets were observed in 3 locations within microvessels: between malaria pigment and leukocytes, associated with malaria pigment, or alone. The mean surface area of platelet staining and the proportion of vessels showing platelet accumulation were significantly higher in patients with CM than in those without it. Platelet accumulation occurs in the microvasculature of patients with CM and may play a role in the pathogenesis of the disease.

Item Type: Article
Subjects: QZ Pathology > QZ 35 Postmortem examination
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 300 Blood platelets
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 340 Nervous system
Digital Object Identifer (DOI):
Depositing User: Martin Chapman
Date Deposited: 17 Jun 2013 15:23
Last Modified: 07 Dec 2018 09:41


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