LSTM Home > LSTM Research > LSTM Online Archive

Nutritional factors in the pathogenesis of ear disease in children: a systematic review

Elemraid, M. A., Mackenzie, Ian, Fraser, W. D. and Brabin, Bernard (2009) 'Nutritional factors in the pathogenesis of ear disease in children: a systematic review'. Annals of Tropical Paediatrics, Vol 29, Issue 2, pp. 85-99.

Full text not available from this repository.

Abstract

Background: Ear disease is a major health problem in poorly resourced countries. The role of nutritional deficiencies in its pathogenesis and in relation to chronic suppurative otitis media (CSOM) has not been reviewed previously. Methods: A systematic review was undertaken using Pubmed, SCOPUS, Cinahl on Ovid, the Cochrane Database and selected medical journals, with no language restriction. Nutritional mechanisms potentially related to ear disease and CSOM risks were reviewed. All studies (observational, case-control, cohort and clinical trials including randomised controlled trials) with nutrition-related information were included. The titles and/or abstracts of all retrieved studies were reviewed and full articles were obtained for relevant studies. Exclusion criteria were multiple publication or studies which did not report nutritional information. Results: Supplementation studies using single micronutrients and vitamins to determine efficacy in reducing acute or chronic otitis media provided some evidence for an association of middle-ear pathology with deficiencies of zinc or vitamin A. Multi-micronutrient supplementation studies provided further support for a beneficial effect, although the number of studies was small and they were heterogeneous and uncontrolled. No human study was identified which specifically examined the association between copper, selenium or vitamin D status and middleear disease or infection. Conclusion: Particularly in developing countries, research on micronutrient status and vitamin deficiency and their influence on middle-ear disease is required to improve knowledge of the pathogenesis of middle-ear infection and to determine the relevance of nutritional interventions in prevention and treatment.

Item Type: Article
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 100 General works
WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders
WS Pediatrics > WS 20 Research (General)
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases
WV Otolaryngology > Diseases. Therapeutics > WV 150 ENT signs, symptoms, and diagnosis. Monitoring
QZ Pathology > Pathogenesis. Etiology > QZ 40 Pathogenesis. Etiology
WV Otolaryngology > Ear > WV 200 General works
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1179/146532809x440707
Depositing User: Pauline Anderson
Date Deposited: 31 Mar 2010 10:04
Last Modified: 06 Feb 2018 12:59
URI: https://archive.lstmed.ac.uk/id/eprint/261

Statistics

View details

Actions (login required)

Edit Item Edit Item