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An island within an island: genetic differentiation of Anopheles gambiae in Sao Tome, West Africa, and its relevance to malaria vector control

Pinto, J., Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Sousa, C. A., Malta-Vacas, J., Gil, V., Ferreira, C., Petrarca, V., do Rosario, V. E. and Charlwood, J. D. (2003) 'An island within an island: genetic differentiation of Anopheles gambiae in Sao Tome, West Africa, and its relevance to malaria vector control'. Heredity, Vol 91, Issue 4, pp. 407-414.

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Abstract

Islands are choice settings for experimental studies of vector control strategies based on transgenic insects. Before considering this approach, knowledge of the population structure of the vector is essential. Genetic variation at 12 microsatellite loci was therefore studied in samples of the malaria vector Anopheles gambiae s.s., collected from six localities of Sao Tome island (West Africa). The objectives were (i) to assess the demographic stability and effective population size of A. gambiae from these sites, (ii) to determine population differentiation and (iii) to relate the observed patterns of population structure with geographic, ecological and historical aspects of the vector on the island. Significant population differentiation, revealed by F-ST and R-ST statistics, was found between the southernmost site, Porto Alegre, and northern localities. The observed patterns of population substructure are probably a result of restrictions to gene flow in the less inhabited, more densely forested and mountainous south. In all localities surveyed, A. gambiae appeared to be experiencing a demographic expansion, consistent with a relatively recent (ca. 500 years) founder effect. The results are discussed with respect to current and future prospects of malaria vector control.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1038/sj.hdy.6800348
Depositing User: Martin Chapman
Date Deposited: 27 Feb 2013 11:46
Last Modified: 06 Feb 2018 13:04
URI: https://archive.lstmed.ac.uk/id/eprint/2647

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