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Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi

Salaniponi, F. M., Nyirenda, T. E., Kemp, J., Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Godfrey-Faussett, P. and Harries, A. D. (2003) 'Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi'. International Journal of Tuberculosis and Lung Disease, Vol 7, Issue 10, pp. 948-952.

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Abstract

SETTING: All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000. OBJECTIVES: To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with recurrent smear-positive pulmonary TB. DESIGN: Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers. RESULTS: There were 748 recurrent patients; data were available for 747. Of these, 487 (65%) successfully completed a re-treatment regimen, 185 (25%) died and the remainder had another outcome. Information about previous TB was recorded for 491 (66%) patients. In 286 (58%) there were 2 years or less between completing and re-starting treatment. Only 307 (41%) patients had sputum sent for culture and drug sensitivity tests. In 164 patients with cultures of Mycobacterium tuberculosis, 122 (81%) were fully sensitive, 25 (15%) had resistance to isoniazid and/or streptomycin, and 6 (4%) had resistance to isoniazid and rifampicin (MDR-TB). CONCLUSION: Patients with recurrent TB had acceptable treatment outcomes, and most had fully sensitive organisms. Over half had recurrent TB 2 years or less after completing treatment. Ways to prevent recurrence need to be investigated and implemented in the field.

Item Type: Article
Additional Information: All back issues (from 1997 up to 6 months previously) are accessible free of charge for all readers.
Uncontrolled Keywords: recurrent smear-positive TB Malawi TB
Subjects: WA Public Health > WA 30 Socioeconomic factors in public health (General)
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
WF Respiratory System > Tuberculosis > WF 310 Therapy
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Related URLs:
Depositing User: Sarah Lewis-Newton
Date Deposited: 03 Sep 2012 14:34
Last Modified: 06 Feb 2018 13:04
URI: https://archive.lstmed.ac.uk/id/eprint/2665

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