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Granulocytes in helminth infection -- who is calling the shots?

Makepeace, Benjamin L., Martin, C, Turner, Joseph and Specht, S (2012) 'Granulocytes in helminth infection -- who is calling the shots?'. Current medicinal chemistry, Vol 19, Issue 10, pp. 1567-86.

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Abstract

Helminths are parasitic organisms that can be broadly described as "worms" due to their elongated body plan, but which otherwise differ in shape, development, migratory routes and the predilection site of the adults and larvae. They are divided into three major groups: trematodes (flukes), which are leaf-shaped, hermaphroditic (except for blood flukes) flatworms with oral and ventral suckers; cestodes (tapeworms), which are segmented, hermaphroditic flatworms that inhabit the intestinal lumen; and nematodes (roundworms), which are dioecious, cylindrical parasites that inhabit intestinal and peripheral tissue sites. Helminths exhibit a sublime co-evolution with the host's immune system that has enabled them to successfully colonize almost all multicellular species present in every geographical environment, including over two billion humans. In the face of this challenge, the host immune system has evolved to strike a delicate balance between attempts to neutralize the infectious assault versus limitation of damage to host tissues. Among the most important cell types during helminthic invasion are granulocytes: eosinophils, neutrophils and basophils. Depending on the specific context, these leukocytes may have pivotal roles in host protection, immunopathology, or facilitation of helminth establishment. This review provides an overview of the function of granulocytes in helminthic infections.

Item Type: Article
Additional Information: Article is available for free at the URL above.
Uncontrolled Keywords: Helminths Eosinophil neutrophil basophil filariasis TH2 response reactive oxygen species reactive nitrogen species nitric oxide hermaphroditic
Subjects: QX Parasitology > Helminths. Annelida > QX 200 Helminths
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 805 Trematode infections (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 830 Cestode infections (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General)
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.2174/092986712799828337
Depositing User: Mary Creegan
Date Deposited: 18 May 2012 10:23
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2838

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