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Cytoadherence and Severe Malaria

Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164, Mustaffa, Khairul and Patil, Pradeep R (2012) 'Cytoadherence and Severe Malaria'. Malaysian Journal of Medical Sciences, Vol 19, Issue 2, pp. 5-18.

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Abstract

Malaria is a disease that causes enormous human morbidity and mortality. One feature of mature Plasmodium falciparum-infected erythrocytes leading to the development of severe malaria is thought to be cytoadherence and blockage of the microvasculature. Therefore, an undersanding of mechnisms that mediate parasite adhesion leading to malaria pathology is needed to yield new treatments for malaria. However, to date, cytoadherence-associated pathology is still under debate. Is cytoadherence needed to develop severe malaria? This review will discuss the available information on associations of cytoadherence with the development of severe malaria.

Item Type: Article
Uncontrolled Keywords: Cerebral malaria, cytoadherence, endothelium, malaria
Subjects: QS Anatomy > Histology > QS 530 Experimental histology
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Depositing User: Mary Creegan
Date Deposited: 06 Jul 2012 10:09
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2862

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