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Detection of Helicobacter pylori DNA in drinking water biofilms: implications for transmission in early life

Bunn, J., MacKay, W. G., Thomas, J. E., Reid, D. C. and Weaver, L. T. (2002) 'Detection of Helicobacter pylori DNA in drinking water biofilms: implications for transmission in early life'. Letters in Applied Microbiology, Vol 34, Issue 6, pp. 450-454.

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Abstract

Aims: To provide evidence of water quality as a risk factor for acquisition of Helicobacter pylori in early life, and to identify evidence for its presence within pots used to store drinking water.
Methods and Results: A prospective cohort study of 65 infants was conducted in the rural village of Keneba, The Gambia. Age of H. pylori colonization was determined and water pot biofilms were tested for H. pylori by sequencing of amplified DNA. Use of supplemental water was a strong risk factor for H. pylori colonization in infants (OR 4.71, 95% CI 1.17-22.5). DNA with 95% homology to the 16S rRNA gene of H. pylori was isolated from biofilms of water pots. Conclusions: Drinking water may be a reservoir for H. pylori in areas of the developing world where water quality is poor. Early introduction of water, particularly if stored in, or collected from contaminated sources, may be associated with an increased rate of H. pylori colonization.

Item Type: Article
Subjects: QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
QW Microbiology and Immunology > QW 51 Morphology and variability of microorganisms. Microbial genetics.
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WA Public Health > Water > WA 675 Water. Water supply. Sources
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1046/j.1472-765X.2002.01122.x
Depositing User: Lynn Roberts-Maloney
Date Deposited: 20 Sep 2013 09:14
Last Modified: 06 Feb 2018 13:04
URI: http://archive.lstmed.ac.uk/id/eprint/2902

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