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Pharmacokinetics of chloroquine in Indian tribal and non-tribal healthy volunteers and patients with Plasmodium falciparum malaria

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Dua, V. K., Gupta, N. C., Kar, P. K., Edwards, Geoffrey, Singh, N. and Sharma, V. P. (2002) 'Pharmacokinetics of chloroquine in Indian tribal and non-tribal healthy volunteers and patients with Plasmodium falciparum malaria'. Current Science, Vol 83, Issue 9, pp. 1128-1131.

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Abstract

The pharmacokinetics of chloroquine was studied in Indian tribal and non-tribal healthy volunteers and patients infected with Plasmodium falciparum malaria, after a single dose of 600-mg chloroquine. Mean area under the curve (AUC), half-life (T-1/2) and peak concentration (C-max) in tribal P. falciparum patients were 18.79 +/- 5.82 mug h ml(-1), 115.94 +/- 57.71 h and 435 +/- 135.17 ng ml(-1) respectively, while in non-tribal P. falciparum patients they were 17.00 +/- 5.60 mug h ml(-1), 76.15 +/- 8.00 h and 454 +/- 193 ng ml(-1) respectively. Pharmacokinetic parameters did not appreciably differ between-tribal and non-tribal groups of subjects in healthy volunteers or in P. falciparum patients. However, the time to reach maximum concentration (T-max) was 8 h in tribal subjects and 4 h in non-tribal subjects. Mean ratio of AUC of chloroquine to desethylchloroquine in tribal P. falciparum patients was higher (4.26 +/- 1.34) than non-tribal subjects (3.41 +/- 0.66), suggesting reduced chloroquine metabolism in tribal subjects. However, the difference was statistically insignificant (t = 1.35, P < 0.5). Delayed T-max and impaired chloroquine metabolism may be associated with general health problems such as malnutrition, anaemia and parasitic infestations of the tribal population in India.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > QV 38 Drug action.
QX Parasitology > Protozoa > QX 135 Plasmodia
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Depositing User: Martin Chapman
Date Deposited: 13 Jun 2013 10:56
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/2911

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