LSTM Home > LSTM Research > LSTM Online Archive

Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

Gray, Carolyn and Craig, Alister (2002) 'Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion'. Infection and Immunity, Vol 70, Issue 7, pp. 3962-3964.

Full text not available from this repository.

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

Item Type: Article
Subjects: QU Biochemistry > Cells and Genetics > QU 375 Cell physiology
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General)
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 310 Mechanism of blood coagulation. Hemostatis
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1128/IAI.70.7.3962-3964.2002
Depositing User: Lynn Roberts-Maloney
Date Deposited: 21 Aug 2013 11:01
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/2928

Statistics

View details

Actions (login required)

Edit Item Edit Item