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A requiem for chloroquine

Hastings, Ian, Bray, Patrick and Ward, Stephen (2002) 'A requiem for chloroquine'. Science, Vol 298, Issue 5591, pp. 74-75.

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Abstract

The arrival of chloroquine resistance in malaria parasites ended the reign of the best and most affordable antimalarial drug ever. The resurgence of malaria in developing countries, particularly in sub-Saharan Africa, is nothing short of a humanitarian disaster. In this Perspective, Hastings and colleagues explore new findings (Sidhu et al.) that reveal how chloroquine resistance evolved. The new work may shed light on appropriate antimalarial drug combinations that do not exhibit cross-resistance, in this way delaying the emergence of resistance to new frontline drugs.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1126/science.1077573
Depositing User: Martin Chapman
Date Deposited: 04 Jun 2013 14:10
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/2935

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