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Biguanide-atovaquone synergy against Plasmodium falciparum in vitro

Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Jones, K. (2002) 'Biguanide-atovaquone synergy against Plasmodium falciparum in vitro'. Antimicrobial Agents and Chemotherapy, Vol 46, Issue 8, pp. 2700-2703.

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Abstract

The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic.

Item Type: Article
Subjects: QV Pharmacology > QV 34 Experimental pharmacology (General)
QX Parasitology > Protozoa > QX 135 Plasmodia
QX Parasitology > QX 45 Host-parasite relations
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1128/aac.46.8.2700-2703.2002
Depositing User: Users 494 not found.
Date Deposited: 21 Jan 2013 12:09
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/2945

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