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Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda

Kaleebu, P., French, Neil, Mahe, C., Yirrell, D., Watera, C., Lyagoba, F., Nakiyingi, J., Rutebemberwa, A., Morgan, D., Weber, J., Gilks, C.F. and Whitworth, J. (2002) 'Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda'. Journal of Infectious Disease, Vol 185, Issue 9, pp. 1244-1250.

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Abstract

The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07-1.56; P = .009) and with a lower CD4 cell count during follow-up (P = .001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Digital Object Identifer (DOI): https://doi.org/10.1086/340130
Depositing User: Martin Chapman
Date Deposited: 28 Feb 2013 09:54
Last Modified: 07 Dec 2018 09:47
URI: http://archive.lstmed.ac.uk/id/eprint/2946

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