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A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

Newton, P. N., Thai, L. H., Tip, N. Q., Short, J. M., Chierakul, W., Rajanuwong, A., Pitisuttithum, P., Chasombat, S., Phonrat, B., Maek-A-Nantawat, W., Teaunadi, R., Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200 and White, N. J. (2002) 'A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis'. Clinical Infectious Diseases, Vol 35, Issue 6, pp. 769-772.

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Abstract

We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

Item Type: Article
Subjects: QV Pharmacology > QV 38 Drug action.
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 245 Meningococcal infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WL Nervous System > WL 200 Meninges. Blood-brain barrier
Digital Object Identifer (DOI): https://doi.org/10.1086/342299
Depositing User: Martin Chapman
Date Deposited: 27 Feb 2013 12:37
Last Modified: 15 Jun 2018 14:31
URI: http://archive.lstmed.ac.uk/id/eprint/2968

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