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Is 'timing' important for cytokine polarization?

Rhodes, Shelley G. and Graham, Simon P. (2002) 'Is 'timing' important for cytokine polarization?'. Trends in Immunology, Vol 23, Issue 5, pp. 246-249.

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Abstract

A comparison of the longitudinal cytokine responses of cattle to infection with intracellular Mycobacterium bovis and extracellular Onchocerca ochengi illustrates the development of reciprocal interferon-gamma and interleukin-4 responses, which result ultimately in an infection-induced type-1 or type-2 polarization, respectively. These kinetic studies of natural host-pathogen relationships show that the cytokine responses to infection fluctuate over time, resulting in periods of polarization and nonpolarization before the establishment of a chronic infection. Here, we discuss our data from cattle in the light of the current understanding of cytokine polarization towards infection in mouse models and humans.

Item Type: Article
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 302 Actinomycetales infections. Mycobacterium infections
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Digital Object Identifer (DOI): https://doi.org/10.1016/s1471-4906(02)02200-7
Depositing User: Lynn Roberts-Maloney
Date Deposited: 26 Jun 2013 12:22
Last Modified: 29 Nov 2018 12:23
URI: http://archive.lstmed.ac.uk/id/eprint/2979

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