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Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.

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Kelly, Matthew J., Benjamin, Laura A., Cartwright, Katharine, Ajdukiewicz, Katherine M.B., Cohen, Danielle B., Menyere, Mavis, Galbraith, Sareen, Guiver, Malcolm, Neuhann, Florian, Solomon, Tom, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200 and Heyderman, Robert S. (2012) 'Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.'. Journal of Infectious Disease, Vol 205, Issue 1, pp. 106-110.

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Abstract

Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.

Item Type: Article
Additional Information: The original version is the electronic one and can be found at: http://jid.oxfordjournals.org/content/205/1/106 Citation: J Infect Dis. (2012) 205 (1): 106-110. doi: 10.1093/infdis/jir707
Subjects: QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 245 Meningococcal infections
WC Communicable Diseases > Virus Diseases > Infectious Viral Skin Diseases > WC 571 Herpesviridae infections
WL Nervous System > WL 200 Meninges. Blood-brain barrier
Digital Object Identifer (DOI): https://doi.org/10.1093/infdis/jir707
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Depositing User: Users 379 not found.
Date Deposited: 12 Sep 2012 14:53
Last Modified: 07 Dec 2018 10:14
URI: http://archive.lstmed.ac.uk/id/eprint/3022

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