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Potential role for mucosally active vaccines against pneumococcal pneumonia

Jambo, Kondwani C., Sepako, Enoch, Heyderman, Robert S. and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2010) 'Potential role for mucosally active vaccines against pneumococcal pneumonia'. Trends in Microbiology, Vol 18, Issue 2, pp. 81-89.

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Abstract

Pneumococcal pneumonia is a life-threatening disease with high mortality and morbidity among children under 5 years of age, the elderly and immunocompromised individuals worldwide. Protection against pneumococcal pneumonia relies on successful regulation of colonisation in the nasopharynx and a brisk alveolar macrophage-mediated immune response in the lung. Therefore, enhancing pulmonary mucosal immunity (which includes a combination of innate, humoral and cell-mediated immunity) through mucosal vaccination might be the key to prevention of pneumococcal infection. Current challenges include a lack of information in humans on mucosal immunity against pneumococci and a lack of suitable adjuvants for new vaccines. Data from mouse models, however, suggest that mucosally active vaccines will enhance mucosal and systemic immunity for protection against pneumococcal infection.

Item Type: Article
Additional Information: This article is an Elsevier "Open Access" article and is available at: http://www.sciencedirect.com/science/article/pii/S0966842X09002571
Subjects: QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.tim.2009.12.001
Depositing User: Users 379 not found.
Date Deposited: 07 Nov 2012 09:49
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/3042

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