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Comparison of Schistosoma mansoni Soluble Cercarial Antigens and Soluble Egg Antigens for Serodiagnosing Schistosome Infections

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Smith, Huw, Doenhoff, Mike, Aitken, Cara, Bailey, Wendi, Ji, Minjun, Dawson, Emily, Gilis, Henk, Spence, Grant, Alexander, Claire and van Gool, Tom (2012) 'Comparison of Schistosoma mansoni Soluble Cercarial Antigens and Soluble Egg Antigens for Serodiagnosing Schistosome Infections'. PLoS Neglected Tropical Diseases, Vol 6, Issue 9, e1815.

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Abstract

A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid – SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories. The performance of SmCTF was compared with that of S. mansoni egg antigens (SmSEA) in an indirect enzyme-immunoassay (ELISA) antigen assay, the latter being used routinely in 3 of the 4 participating laboratories to diagnose S. mansoni and S. haematobium infections. In the fourth laboratory the performance of SmCTF was compared with that of S. japonicum egg antigens (SjSEA) in ELISA for detection of anti-S. japonicum antibodies. In all 4 laboratories the results given by SmCTF in ELISA were very similar to those given by the antigen preparation routinely used in the respective laboratory to detect anti-schistosome antibodies in human infection sera. In so far as the ELISA results from SmCTF are thus so little different from those given by schistosome egg antigens and also cheaper to produce, the former is a potentially useful new diagnostic aid for schistosomiasis.

Item Type: Article
Additional Information: The electronic version is the original one and can be found at: http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001815
Subjects: QX Parasitology > Helminths. Annelida > QX 355 Schistosoma
QY Clinical Pathology > QY 4 General works
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1371/journal.pntd.0001815
Depositing User: Users 379 not found.
Date Deposited: 26 Oct 2012 14:14
Last Modified: 06 Feb 2018 13:05
URI: https://archive.lstmed.ac.uk/id/eprint/3066

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