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Latex agglutination test for the detection of urinary antigens in visceral leishmaniasis

Attar, Zamil J, Chance, Michael, el-Safi, S., Carney, J., Azazy, A., El-Hadi, M., Dourado, Cibele and Hommel, Marcel (2001) 'Latex agglutination test for the detection of urinary antigens in visceral leishmaniasis'. Acta Tropica, Vol 78, Issue 1, pp. 11-16.

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Abstract

This paper describes a new latex agglutination test ('KATEX') for the detection of leishmanial antigen in the urine of patients with visceral leishmaniasis. In preliminary laboratory trials, using urine collected from well-defined cases and controls from Brazil, Yemen and Nepal, the test had 100% specificity and a sensitivity between 68 and 100%. When used in a time-course experiment in cotton rats infected with Leishmania donovani, the test became positive 1 week after inoculation and antigen levels in urine declined rapidly after chemotherapy (the test was negative before the end of the course of treatment). Finally, in an integrated study performed in Sudan, KATEX was compared to microscopy and four different serological tests in a group of 73 patients having presented with clinical manifestations suggestive of visceral leishmaniasis. Compared to microscopy, KATEX performed better than any single serological test in predicting positivity and a particularly good result was obtained by combining KATEX and the direct agglutination test (DAT).

Item Type: Article
Subjects: QY Clinical Pathology > Diagnostic Tests > QY 185 Urinalysis
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis
Faculty: Department: Pre 2002
Digital Object Identifer (DOI): https://doi.org/10.1016/s0001-706x(00)00155-8
Depositing User: Lynn Roberts-Maloney
Date Deposited: 25 Sep 2013 10:32
Last Modified: 06 Feb 2018 13:05
URI: https://archive.lstmed.ac.uk/id/eprint/3106

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