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Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus infected Malawian adults

Gordon, Stephen, Molyneux, Malcolm E, Boeree, M. J., Kanyanda, S., Chaponda, M., Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038 and Read, R. C. (2001) 'Opsonic phagocytosis of Streptococcus pneumoniae by alveolar macrophages is not impaired in human immunodeficiency virus infected Malawian adults'. Journal of Infectious Disease, Vol 184, Issue 10, pp. 1345-1349.

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Abstract

Streptococcus pneumoniae is a major cause of pneumonia, bacteremia, and meningitis, especially among adults infected with the human immunodeficiency virus (HIV). Alveolar macrophages (AMs) are critical components of cellular defense against bacterial infection and are both infected and affected by HIV. In this study, AMs obtained at bronchoscopy from 44 Malawian adults (24 HIV positive and 20 HIV negative) were exposed in vitro to opsonized S. pneumoniae and coagulase-negative staphylococci. AMs from HIV-positive and -negative volunteers showed no significant difference in binding to or internalization of either S. pneumoniae or coagulase-negative staphylococci. In HIV-positive subjects, the presence of detectable HIV in lung fluid was not associated with AM impairment. AMs from HIV-infected adults did not exhibit impaired pneumococcal phagocytosis in the assay used. This suggests that an alternative mechanism of susceptibility is operating in these individuals.

Item Type: Article
Subjects: WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WF Respiratory System > WF 140 Diseases of the respiratory system (General)
WH Hemic and Lymphatic Systems > Lymphatic System > WH 650 Reticuloendothelial system
Digital Object Identifer (DOI): https://doi.org/10.1086/324080
Depositing User: Martin Chapman
Date Deposited: 30 Jul 2013 14:36
Last Modified: 07 Dec 2018 09:44
URI: http://archive.lstmed.ac.uk/id/eprint/3146

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