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Malaria in infants aged less than six months - is it an area of unmet medical need?

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D'Alessandro, Umberto, Ubben, David, Hamed, Kamal, Ceesay, Serign Jawo, Okebe, Joseph, Taal, Makie, Kaman Lama, Eugene, Keita, Moussa, Koivogui, Lamine, Nahum, Alain, Bojang, Kalifa, Sonko, Aja Adam Jagne, Lalya, Honorat Francis and Brabin, Bernard (2012) 'Malaria in infants aged less than six months - is it an area of unmet medical need?'. Malaria Journal, Vol 11, :400.

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Abstract

Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WS Pediatrics > By Age Groups > WS 420 Newborn infants. Neonatology
WS Pediatrics > By Age Groups > WS 421 Diseases of newborn infants
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1475-2875-11-400
Depositing User: Julie Franco
Date Deposited: 05 Feb 2013 12:45
Last Modified: 06 Feb 2018 13:05
URI: https://archive.lstmed.ac.uk/id/eprint/3224

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