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Maternal Geohelminth Infections are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study.

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Mehta, Raaj S, Rodriguez, Alejandro, Chico, Martha, Guadalupe, Irene, Broncano, Nely, Sandoval, Carlos, Tupiza, Fernanda, Mitre, Edward and Cooper, Philip (2012) 'Maternal Geohelminth Infections are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study.'. PLoS Neglected Tropical Diseases, Vol 6, Issue 7, e1753.

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Abstract

BACKGROUND

Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection.

METHODS AND FINDINGS

We did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7 months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third trimester of pregnancy. The analysis was restricted to households with a documented infection to control for infection risk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR 2.61, 95% CI: 1.88-3.63, p<0.001). This effect was particularly strong in children of mothers with both STH infections (adjusted OR: 5.91, 95% CI: 3.55-9.81, p<0.001). Newborns of infected mothers had greater levels of plasma IL-10 than those of uninfected mothers (p=0.033), and there was evidence that cord blood IL-10 was increased among newborns who became infected later in childhood (p=0.060).

CONCLUSION

Our data suggest that maternal STH infections increase susceptibility to infection during early childhood, an effect that was associated with elevated IL-10 in cord plasma.

Item Type: Article
Subjects: QX Parasitology > Helminths. Annelida > QX 200 Helminths
WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 800 Helminthiasis
WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases
WS Pediatrics > By Age Groups > WS 430 Infancy
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1371/journal.pntd.0001753
Depositing User: Mary Creegan
Date Deposited: 05 Apr 2013 10:01
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/3259

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