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Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence.

Cruz, Laura N, Wu, Yang, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 and Garcia, Célia R S (2012) 'Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence.'. Anais da Academia Brasileira de Ciências, Vol 84, Issue 2, pp. 555-72.

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Abstract

Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al. 2011) there is still a relative low investment toward antimalarial drugs. Briefly there are targets classes of antimalarial drugs currently being tested including: kinases, proteases, ion channel of GPCR, nuclear receptor, among others (Gamo et al. 2010). Here we review malaria signal transduction pathways in Red Blood Cells (RBC) as well as infected RBCs and endothelial cells interactions, namely cytoadherence. The last process is thought to play an important role in the pathogenesis of severe malaria. The molecules displayed on the surface of both infected erythrocytes (IE) and vascular endothelial cells (EC) exert themselves as important mediators in cytoadherence, in that they not only induce structural and metabolic changes on both sides, but also trigger multiple signal transduction processes, leading to alteration of gene expression, with the balance between positive and negative regulation determining endothelial pathology during a malaria infection.

Item Type: Article
Uncontrolled Keywords: cytoadherence, erythrocyte, malaria, Plasmodium, signal transduction
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 150 Erythrocytes
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1590/S0001-37652012005000036
Depositing User: Mary Creegan
Date Deposited: 05 Mar 2013 16:19
Last Modified: 06 Feb 2018 13:05
URI: http://archive.lstmed.ac.uk/id/eprint/3261

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