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Nanocarriers targeting dendritic cells for pulmonary vaccine delivery.

Kunda, Nitesh K, Somavarapu, Satyanarayana, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Hutcheon, Gillian A and Saleem, Imran Y (2013) 'Nanocarriers targeting dendritic cells for pulmonary vaccine delivery.'. Pharmaceutical research, Vol 30, Issue 2, pp. 325-41.

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Abstract

Pulmonary vaccine delivery has gained significant attention as an alternate route for vaccination without the use of needles. Immunization through the pulmonary route induces both mucosal and systemic immunity, and the delivery of antigens in a dry powder state can overcome some challenges such as cold-chain and availability of medical personnel compared to traditional liquid-based vaccines. Antigens formulated as nanoparticles (NPs) reach the respiratory airways of the lungs providing greater chance of uptake by relevant immune cells. In addition, effective targeting of antigens to the most 'professional' antigen presenting cells (APCs), the dendritic cells (DCs) yields an enhanced immune response and the use of an adjuvant further augments the generated immune response thus requiring less antigen/dosage to achieve vaccination. This review discusses the pulmonary delivery of vaccines, methods of preparing NPs for antigen delivery and targeting, the importance of targeting DCs and different techniques involved in formulating dry powders suitable for inhalation.

Item Type: Article
Subjects: QV Pharmacology > Pharmaceutical Processes. Packaging. Labeling > QV 785 Types of pharmaceutical preparations. Dosage forms
QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
WF Respiratory System > WF 20 Research (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1007/s11095-012-0891-5
Depositing User: Julie Franco
Date Deposited: 06 Mar 2013 16:39
Last Modified: 06 Feb 2018 13:06
URI: http://archive.lstmed.ac.uk/id/eprint/3338

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