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Treatment outcome in children with tuberculosis in southern Ethiopia

Munoz-Sellart, M., Yassin, Mohammed A., Tumato, M., Merid, Y. and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2009) 'Treatment outcome in children with tuberculosis in southern Ethiopia'. Scandinavian Journal of Infectious Diseases, Vol 41, Issue 6-7, pp. 450-455.

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Abstract

Our study took place at 8 tuberculosis diagnostic and treatment centres in Sidama Zone, southern Ethiopia. Our objectives were to assess the status of TB treatment in children and risk factors associated with unfavourable outcome. A retrospective study was based on information retained in TB registers of the centres. Demographic characteristics and treatment outcome of children registered between 2002 and 2007 were retrieved. Risk factors for unfavourable outcome (failure, default or death) were calculated. Of 851 (165 with smear-positive, 475 smear-negative and 206 extrapulmonary TB) children, 655 (77%) were cured or completed and 124 (14.6%) had unfavourable outcome. Treatment success rate increased with age from 66% in children <5 y old to 81% in 5-9-y-olds and 85% in >= 10-y-olds (p <0.001). 75% of patients with smear-negative TB had favourable outcome compared to 80.6% for smear-positive cases (p = 0.06). Age < 5 y, lack of smear conversion in the second month and living in rural areas were independent risk factors for unfavourable treatment outcome. In conclusion, the outcome of TB treatment varies with age, residency and smear results. Reporting only cases with smear-positive TB disproportionally excludes a higher proportion of children than adults. Surveillance systems to monitor TB outcome in children need to be improved.

Item Type: Article
Subjects: WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WA Public Health > Preventive Medicine > WA 243 Diagnositic services
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 141 General works
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 200 Physical diagnosis (General)
WF Respiratory System > Tuberculosis > WF 415 Tuberculosis in childhood
WF Respiratory System > Tuberculosis > WF 215 Pathology
WF Respiratory System > Tuberculosis > WF 310 Therapy
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1080/00365540902865736
Depositing User: Pauline Anderson
Date Deposited: 05 Mar 2010 10:35
Last Modified: 06 Feb 2018 12:59
URI: http://archive.lstmed.ac.uk/id/eprint/339

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