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A model of parity-dependent immunity to placental malaria

Walker, Patrick G.T., Griffin, Jamie T., Cairns, Matt, Rogerson, Stephen J., van Eijk, Anna ORCID: https://orcid.org/0000-0003-1635-1289, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617 and Ghani, Azra C. (2013) 'A model of parity-dependent immunity to placental malaria'. Nature Communications, Vol 4, Article no. 1609.

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Abstract

Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection.

Item Type: Article
Uncontrolled Keywords: Biological sciences; Immunology; Medical research
Subjects: WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WP Gynecology > Anatomy. Diseases. Injuries > WP 140 Diseases (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1038/ncomms2605
Depositing User: Users 27 not found.
Date Deposited: 17 Mar 2014 16:46
Last Modified: 16 Aug 2019 13:40
URI: https://archive.lstmed.ac.uk/id/eprint/3399

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