Improved method for assessing iron stores in the bone marrow

Phiri, K. S., Calis, J. C. J., Kachala, D., Borgstein, E., Waluza, J., Bates, Imelda ORCID: https://orcid.org/0000-0002-0862-8199, Brabin, Bernard and Boele van Hensbroek, Michael (2009) 'Improved method for assessing iron stores in the bone marrow'. Journal of Clinical Pathology, Vol 62, Issue 8, pp. 685-689.

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Abstract

Background: Bone marrow iron microscopy has been the "gold standard'' method of assessing iron deficiency. However, the commonly used method of grading marrow iron remains highly subjective. Aim: To improve the bone marrow grading method by developing a detailed protocol that assesses iron in fragments, in macrophages around fragments and in erythroblasts. Methods: A descriptive study of marrow aspirates of 303 children (aged 6-60 months) with severe anaemia and 22 controls (children undergoing elective surgery) was conducted at hospitals in southern Malawi (2002-04). Results: Using an intensive marrow iron grading method, 22% and 39% of cases and controls had deficient iron stores, and 40% and 46% had functional iron deficiency, respectively. Further evaluation of the iron status classification by the intensive method showed that functional iron deficiency was associated with significantly increased C-reactive protein concentrations (126.7 (85.6) mg/l), and iron stores deficiency with significantly increased soluble transferrin receptor concentrations (21.7 (12.5) mg/ml). Conclusions: Iron assessment can be greatly improved by a more intense marrow examination. This provides a useful iron status classification which is of particular importance in areas where there is a high rate of inflammatory conditions.

Item Type:	Article
Additional Information:	Phiri, K. S. Calis, J. C. J. Kachala, D. Borgstein, E. Waluza, J. Bates, I. Brabin, B. van Hensbroek, M. Boele
Uncontrolled Keywords:	Anaemia Bone Marrow Iron Stores
Subjects:	WA Public Health > WA 30 Socioeconomic factors in public health (General) WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WH Hemic and Lymphatic Systems > WH 100 General works WH Hemic and Lymphatic Systems > WH 20 Research (General) WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases QY Clinical Pathology > QY 4 General works
Digital Object Identifer (DOI):	https://doi.org/10.1136/jcp.2009.064451
Depositing User:	Pauline Anderson
Date Deposited:	26 Mar 2010 14:35
Last Modified:	22 Oct 2019 08:20
URI:	https://archive.lstmed.ac.uk/id/eprint/364

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