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Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.

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Moxon, Christopher A., Chisala, Ngawina V, Wassmer, Samuel C, Taylor, Terrie E, Seydel, Karl B, Molyneux, Malcolm E, Faragher, Brian, Kennedy, Neil, Toh, Cheng-Hock, Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 and Heyderman, Robert (2014) 'Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.'. Journal of Infectious Disease, Vol 209, Issue 4, pp. 610-615.

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Abstract

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

Item Type: Article
Subjects: QS Anatomy > Histology > QS 532.5.E7 Epithelium
QU Biochemistry > Cells and Genetics > QU 375 Cell physiology
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WS Pediatrics > WS 20 Research (General)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/infdis/jit419
Depositing User: Mary Creegan
Date Deposited: 16 Apr 2014 09:29
Last Modified: 17 Jul 2019 14:14
URI: https://archive.lstmed.ac.uk/id/eprint/3666

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