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Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

Attardo, G. M., Abila, P. P., Auma, J. E., Baumann, A. A., Benoit, J. B., Brelsfoard, C. L., Ribeiro, J. M. C., Cotton, J. A., Pham, D. Q. D., Darby, Alistair C., Van Den Abbeele, J., Denlinger, D. L., Field, L. M., Nyanjom, S. R. G., Gaunt, M. W., Geiser, D. L., Gomulski, L. M., Haines, Lee ORCID: https://orcid.org/0000-0001-8821-6479, Hansen, I. A., Jones, J. W., Kibet, C. K., Kinyua, J. K., Larkin, D. M., Lehane, Mike, Rio, R. V. M., Macdonald, S. J., Macharia, R. W., Malacrida, A. R., Marco, H. G., Marucha, K. K., Masiga, D. K., Meuti, M. E., Mireji, P. O., Obiero, G. F. O., Koekemoer, J. J. O., Okoro, C. K., Omedo, I. A., Osamor, V. C., Balyeidhusa, A. S. P., Peyton, J. T., Price, D. P., Quail, M. A., Ramphul, U., Rawlings, N. D., Riehle, M. A., Robertson, H. M., Sanders, M. J., Scott, M. J., Dashti, Z. J. S., Snyder, A. K., Srivastava, T. P., Stanley, E. J., Swain, M. T., Hughes, D. S. T., Tarone, A. M., Taylor, T. D., Telleria, E. L., Thomas, G. H., Walshe, Deirdre ORCID: https://orcid.org/0000-0001-5531-2368, Wilson, R. K., Winzerling, J. J., Acosta Serrano, Alvaro, Aksoy, S., Arensburger, P., Aslett, M., Bateta, R., Benkahla, A., Berriman, M., Bourtzis, K., Caers, J., Caljon, G., Christoffels, A., Falchetto, M., Friedrich, M., Fu, S., Gade, G., Githinji, G., Gregory, R., Hall, N., Harkins, G., Hattori, M., Hertz-Fowler, C., Hide, W., Hu, W., Imanishi, T., Inoue, N., Jonas, M., Kawahara, Y., Koffi, M., Kruger, A., Lawson, D., Lehane, Stella, Lehvaslaiho, H., Luiz, T., Makgamathe, M., Malele, I., Manangwa, O., Manga, L., Megy, K., Michalkova, V., Mpondo, F., Mramba, F., Msangi, A., Mulder, N., Murilla, G., Mwangi, S., Okedi, L., Ommeh, S., Ooi, Cher-Pheng, Ouma, J., Panji, S., Ravel, S., Rose, Clair ORCID: https://orcid.org/0000-0001-7782-5359, Sakate, R., Schoofs, L., Scolari, F., Sharma, V., Sim, C., Siwo, G., Solano, P., Stephens, D., Suzuki, Y., Sze, S.-H., Toure, Y., Toyoda, A., Tsiamis, G., Tu, Z., Wamalwa, M., Wamwiri, F., Wang, J., Warren, W., Watanabe, J., Weiss, B., Willis, J., Wincker, P., Zhang, Q. and Zhou, J.-J. (2014) 'Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis'. Science, Vol 344, Issue 6182, pp. 380-386.

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Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Item Type: Article
Additional Information: Published by the members of the International Glossina Genome Initiative (IGGI).
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QX Parasitology > Insects. Other Parasites > QX 505 Diptera
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1126/science.1249656
Depositing User: Martin Chapman
Date Deposited: 08 May 2014 10:40
Last Modified: 01 Jun 2018 14:57
URI: http://archive.lstmed.ac.uk/id/eprint/3682

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