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Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.

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Uthman, Olalekan A., Saunders, Rachel, Sinclair, David, Graves, Patricia, Gelband, Helen, Clarke, Aileen and Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941 (2014) 'Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.'. British Medical Journal (BMJ), Vol 4, Issue 5, e004664.

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Abstract

INTRODUCTION:

A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes. Primaquine is also known to cause haemolysis in people with variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency. The objective of this systematic review was to assess the risk of adverse effects in people with G6PD deficiency given primaquine or other 8-aminoquinoline (8AQ) as a single dose or short course (less than 7 days).

METHODS AND ANALYSIS:

We will search the following databases: Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. Prospective cohort studies, randomised and quasi-randomised trials that evaluated 8AQs for whatever reason in adults or children with a known G6PD deficiency will be included. Two authors will independently assess each study for eligibility, risk of bias and extract data.

ETHICS AND DISSEMINATION:

This systematic review will be published in a peer-reviewed journal. Brief reports of the review findings will be disseminated directly to the appropriate audiences and the WHO Technical Expert Group in Malaria Chemotherapy. As no primary data collection will be undertaken, no additional formal ethical assessment and informed consent are required.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 258 Primaquine. Quinacrine
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 155 Anemia
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1136/bmjopen-2013-004664.
Depositing User: Christianne Esparza
Date Deposited: 30 May 2014 08:40
Last Modified: 06 Feb 2018 13:07
URI: https://archive.lstmed.ac.uk/id/eprint/3721

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