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Complex cocktails: the evolutionary novelty of venoms.

Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719, Wüster, Wolfgang, Vonk, Freek J, Harrison, Robert and Fry, Bryan G (2013) 'Complex cocktails: the evolutionary novelty of venoms.'. Trends in Ecology & Evolution, Vol 28, Issue 4, pp. 219-229.

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Abstract

Venoms have evolved on numerous occasions throughout the animal kingdom. These 'biochemical weapon systems' typically function to facilitate, or protect the producing animal from, predation. Most venomous animals remain unstudied despite venoms providing model systems for investigating predator-prey interactions, molecular evolution, functional convergence, and novel targets for pharmaceutical discovery. Through advances in 'omic' technologies, venom composition data have recently become available for several venomous lineages, revealing considerable complexity in the processes responsible for generating the genetic and functional diversity observed in many venoms. Here, we review these recent advances and highlight the ecological and evolutionary novelty of venom systems.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QV Pharmacology > Toxicology > General Toxicology > QV 600 General works
QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1016/j.tree.2012.10.020
Depositing User: Mary Creegan
Date Deposited: 02 Jul 2014 10:56
Last Modified: 06 Feb 2018 13:07
URI: http://archive.lstmed.ac.uk/id/eprint/3777

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