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Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis--a rapid assessment methodology to assess impact

Mohammed, Khalfan A, Deb, Rinki, Stanton, Michelle and Molyneux, David (2012) 'Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis--a rapid assessment methodology to assess impact'. Parasites & Vectors, Vol 5, e299.

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Abstract

BACKGROUND

Ivermectin and albendazole are used in annual mass drug administration (MDA) for the lymphatic filariasis elimination programmes in African countries co-endemic for onchocerciasis, but have additional impact on soil transmitted helminths and the ectoparasitic mite which causes scabies. Assessing these collateral impacts at scale is difficult due to the insensitivity of available parasite detection techniques.

METHODS

The numbers of cases diagnosed with intestinal helminths and scabies and who received prescriptions for treatment were evaluated in 50 health centres in Zanzibar. Records were examined from 2000, prior to the initiation of MDA to 2005, after six rounds of MDA for lymphatic filariasis had taken place.

RESULTS

Health centre records showed a consistent decline in the number of cases of intestinal helminths and scabies diagnosed by community health workers in Zanzibar and the number of prescriptions issued across five age groups. A 90-98% decline in soil transmitted helminths and 68-98% decline in scabies infections were recorded. Poisson regression models aggregated to both the island-level and district-level indicated that the decline was statistically significant.

CONCLUSIONS

The described method of examining health centre records has the potential for use on a large scale, despite limitations, as a rapid method to evaluate the impacts resulting from both lymphatic filariasis and onchocerciasis MDA. This would result in a reduction in the need for parasitological evaluations to determine prevalence and intensity.

Item Type: Article
Additional Information: The electronic version of this article is the complete one and can be found online at: http://www.parasitesandvectors.com/content/5/1/299
Subjects: W General Medicine. Health Professions > W 26.5 Informatics. Health informatics
QX Parasitology > QX 20 Research (General)
QX Parasitology > Helminths. Annelida > QX 200 Helminths
QX Parasitology > Arthropods > QX 475 Sarcoptidae (Mites) (e.g., Sarcoptes scabiei)
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 900 Ectoparasitic infestations, disinfestation (General)
WR Dermatology > Parasitic Skin Diseases > WR 365 Scabies
WX Hospitals and Other Health Facilities > Hospital Administration > WX 173 Medical records
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1756-3305-5-299
Depositing User: Mary Creegan
Date Deposited: 23 Jul 2014 11:47
Last Modified: 06 Feb 2018 13:07
URI: http://archive.lstmed.ac.uk/id/eprint/3808

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