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Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations

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Bangert, Mathieu, Wright, Adam, Rylance, J., Kelly, M. J., Wright, Angela, Carlone, G. M., Sampson, J. S., Rajam, G., Ades, E. W., Kadioglu, A. and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2013) 'Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations'. Antimicrobial Agents and Chemotherapy, Vol 57, Issue 9, pp. 4566-4569.

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Abstract

New treatment strategies are urgently needed to overcome early mortality in acute bacterial infections. Previous studies have shown that administration of a novel immunoactivating peptide (P4) alongside passive immunotherapy prevents the onset of septicemia and rescues mice from lethal invasive disease models of pneumococcal pneumonia and sepsis. In this study, using two diverse populations of adult volunteers, we determined whether P4 treatment of human alveolar macrophages would upregulate phagocytic killing of Streptococcus pneumoniae ex vivo. We also measured macrophage intracellular oxidation, cytokine secretion, and surface marker expression following stimulation. Peptide treatment showed enhanced bacterial killing in the absence of nonspecific inflammation, consistent with therapeutic potential. This is the first demonstration of P4 efficacy on ex vivo-derived human lung cells.

Item Type: Article
Subjects: QU Biochemistry > Proteins. Amino Acids. Peptides > QU 68 Peptides
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 800 Biological products producing immunity
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 200 Bacterial infections (General or not elsewhere classified)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1128/AAC.00742-13
Depositing User: Lynn Roberts-Maloney
Date Deposited: 11 Nov 2014 10:04
Last Modified: 23 Feb 2018 09:30
URI: http://archive.lstmed.ac.uk/id/eprint/4564

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