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Developing regional weight-for-age growth references to optimize age-based dosing of antimalarials

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Hayes, Daniel, Buuren, Stef van, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617, Stasinopoulos, D Mikis, Rigby, Robert A and Terlouw, Anja (2015) 'Developing regional weight-for-age growth references to optimize age-based dosing of antimalarials'. Bulletin of the World Health Organization, Vol 93, Issue 2, pp. 74-83.

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Figure S2. country medians Africa F.pdf

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Abstract

Objective To derive regional weight-for-age growth references to help optimize age-based dosing of antimalarials in malaria-endemic areas of Africa, Latin America and Asia by using existing anthropometric data.

Methods A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) aged over 14 days and under 50 years in 64 malaria-endemic countries. Regional growth references were generated using a generalized additive model for location, scale and shape by combining multisource data with varying distributions and subsequently pooling the data. Countries were weighted by their population at risk of malaria to enable references to be used in optimizing the dosing of antimalarials.
Findings Large differences in weight-for-age distributions existed between Africa, Latin America and Asia and between these regions and global growth standards. For example, the average adult Latin American male weighed 68.1 kg – 6 kg more than males in Asia (average: 62.1 kg). For adult women, the difference was over 10 kg: the average was 60.4 kg in Latin America and 50.0 kg in Asia.

Conclusion There were substantial variations in weight-for-age growth curves between malaria-endemic areas of Africa, Latin America and Asia. The growth reference charts derived here can be used to guide the evidence-based optimization of aged-based dosing regimens for antimalarials and of other drugs often prescribed by age.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.2471/BLT.14.139113
Depositing User: Helen Wong
Date Deposited: 10 Nov 2014 16:29
Last Modified: 31 May 2018 13:21
URI: http://archive.lstmed.ac.uk/id/eprint/4566

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