LSTM Home > LSTM Research > LSTM Online Archive

Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection

Bogoch, Isaac I., Coulibaly, Jean T., Andrews, Jason R., Speich, Benjamin, Keiser, Jennifer, Stothard, Russell, N'Goran, Eliézer K. and Utzinger, Jürg (2014) 'Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection'. Parasitology, Vol 141, Issue 14, pp. 1811-1818.

Full text not available from this repository.

Abstract

SUMMARY: The diagnosis of parasitic worm (helminth) infections requires specialized laboratory settings, but most affected individuals reside in locations without access to such facilities. We tested two portable microscopic devices for the diagnosis of helminth infections in a cross-sectional survey in rural Côte d'Ivoire. We examined 164 stool samples under a light microscope and then re-examined with a commercial portable light microscope and an experimental mobile phone microscope for the diagnosis of Schistosoma mansoni and soil-transmitted helminths. Additionally, 180 filtered urine samples were examined by standard microscopy and compared with the portable light microscope for detection of Schistosoma haematobium eggs. Conventional microscopy was considered the diagnostic reference standard. For S. mansoni, S. haematobium and Trichuris trichiura, the portable light microscope showed sensitivities of 84·8%, 78·6% and 81·5%, respectively, and specificities of 85·7%, 91·0% and 93·0%, respectively. For S. mansoni and T. trichiura, we found sensitivities for the mobile phone microscope of 68·2% and 30·8%, respectively, and specificities of 64·3% and 71·0%, respectively. We conclude that the portable light microscope has sufficient diagnostic yield for Schistosoma and T. trichiura infections, while the mobile phone microscope has only modest sensitivity in its current experimental set-up. Development of portable diagnostic technologies that can be used at point-of-sample collection will enhance diagnostic coverage in clinical and epidemiological settings.

Item Type: Article
Additional Information: Special Issue - Symposia of the British Society for Parasitology Volume 52 Advances in diagnostics for parasitic diseases.
Subjects: QX Parasitology > Helminths. Annelida > QX 200 Helminths
QX Parasitology > Helminths. Annelida > QX 207 Trichuroidea
QX Parasitology > Helminths. Annelida > QX 355 Schistosoma
QY Clinical Pathology > QY 25 Laboratory techniques and procedure
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 141 General works
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 860 Trichuriasis. Oxyuriasis
Faculty: Department: Biological Sciences > Parasitology Department
Digital Object Identifer (DOI): https://doi.org/10.1017/S0031182014000432
Depositing User: Martin Chapman
Date Deposited: 03 Dec 2014 12:18
Last Modified: 06 Feb 2018 13:08
URI: http://archive.lstmed.ac.uk/id/eprint/4613

Statistics

View details

Actions (login required)

Edit Item Edit Item