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Unusual norovirus and rotavirus genotypes in Ethiopia

Yassin, Mohammed A., Kirby, Andrew, Mengistu, Abebayehu A, Arbide, Isabel, Dove, Winifred, Beyer, Mandy, Cunliffe, Nigel A and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2012) 'Unusual norovirus and rotavirus genotypes in Ethiopia'. Paediatrics and International Child Health, Vol 32, Issue 1, pp. 51-55.

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Abstract

Background: Gastro-enteritis is associated with significant mortality in low- and middle-income countries, and rotavirus and norovirus are the principal viral agents implicated.
Aims: To investigate the molecular epidemiology and burden of disease associated with rotavirus and norovirus in children attending a health centre in Ethiopia.
Methods: A cross-sectional study was conducted in children attending a health centre in Awassa, southern Ethiopia. Children with diarrhoea (cases) and without diarrhoea (controls) were recruited over a 6-month period from December 2008 to May 2009. Rotavirus was detected by ELISA and genotyped by RT-PCR, and norovirus was amplified by RT-PCR with genotyping by sequence analysis of RT-PCR products.
Results: Rotavirus was detected in 44/200 (22%) cases and in none of the controls, with genotypes G3P[6] (48%), G1P[8] (27%) and G2P[4] (7%) being the strains most commonly identified. Norovirus was detected in 16 (8%) of 200 cases and in 4 (7%) of 57 controls. Norovirus GII.3 was the strain most commonly detected (40%: 8/20) and ten other genotypes were also detected.
Conclusion: Rotavirus is a common cause of severe gastro-enteritis in children in Ethiopia; however, norovirus occurred with a similar frequency in cases and controls. A globally uncommon strain type, G3P[6], predominated within the rotavirus strains detected.

Item Type: Article
Uncontrolled Keywords: Children Diarrhoea Ethiopia Norovirus Rotavirus
Subjects: QU Biochemistry > Genetics > QU 500 Genetic phenomena
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > General RNA Virus Infections > WC 501 RNA virus infections (General or not elsewhere classified)
WI Digestive System > WI 140 Diseases (General)
WI Digestive System > WI 20 Research (General)
WI Digestive System > WI 407 Diarrhea
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1179/1465328111y.0000000047
Depositing User: Martin Chapman
Date Deposited: 08 Dec 2014 12:17
Last Modified: 06 Feb 2018 13:08
URI: http://archive.lstmed.ac.uk/id/eprint/4623

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