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Prevalence of Raised Intracranial Pressure in Cerebral Malaria Detected by Optic Nerve Sheath Ultrasound

Beare, N. A. V., Glover, S. J., Lewallen, S., Taylor, T. E., Harding, S. P. and Molyneux, Malcolm E (2012) 'Prevalence of Raised Intracranial Pressure in Cerebral Malaria Detected by Optic Nerve Sheath Ultrasound'. American Journal of Tropical Medicine and Hygiene, Vol 87, Issue 6, pp. 985-988.

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Abstract

We aimed to use optic nerve sheath (ONS) ultrasound to determine the prevalence of raised intracranial pressure (ICP) in African children with cerebral malaria (CM); and if increased ONS diameter is associated with poor outcome. We measured ONS diameter in 101 children with CM and 11 children with malaria and impaired consciousness in Malawi. The prevalence of raised ICP detected by increased ONS diameter was 49%. Case fatality was similar in children with increased ONS diameter on admission (9/55) and those children without increased ONS diameter (11/57). Neurological sequelae were more common in those children with increased ONS diameter (7/46 versus 2/46, P < 0.05). Lumbar puncture (LP) opening pressure was elevated in 95% of 46 children who underwent LP. In Malawian children with CM, raised ICP is less commonly detected by ONS ultrasound than LP. This study suggests that raised ICP is not universal in CM and that other mechanisms may account for coma.

Item Type: Article
Subjects: WL Nervous System > WL 20 Research (General)
WL Nervous System > Sense Organs > WL 700 General works
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 340 Nervous system
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.4269/ajtmh.2012.11-0459
Depositing User: Lynn Roberts-Maloney
Date Deposited: 11 Dec 2014 12:25
Last Modified: 06 Feb 2018 13:08
URI: https://archive.lstmed.ac.uk/id/eprint/4642

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